SAZINSKY, Stephen,MICHAELSON, Jennifer S.,SATHYANARAYANAN, Sriram,ELPEK, Kutlu Goksu
申请号：
PH12017501748
公开号：
PH12017501748A1
申请日:
2017.09.22
申请国别(地区):
PH
年份:
2018
代理人:
摘要：
Provided herein are various embodiments relating to antibodies. Some of the embodiments include agonist antibodies that bind ICOS. Such antibodies can be used in methods to treat, for example, cancer. In some embodiments, an isolated antibody that binds ICOS is provided, wherein the antibody is an agonist of CD4 T cells (such as CD4 T effector (Teff) cells). In some embodiments, an isolated antibody that binds ICOS is provided, wherein the antibody is an agonist of CD4 T cells (such as CD4 Teff cells) and depletes T regulatory (Treg) cells. In some embodiments, an isolated antibody that binds ICOS is provided, wherein the antibody depletes Treg cells, but does not deplete Teff cells.
