Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd.
发明人:
申请号：
EP18789707.9
公开号：
EP3684417A1
申请日:
2018.09.17
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates to methods of preparing peptide-based prodrugs having enhanced oral bioavailability and intestinal penetration. Said prodrugs are characterized in improved lipophilicity, reduced electric charge and tendency to undergo biotransformation through enzymatic reaction (e.g. in the blood stream) to form biologically active peptides.
