WROBEL, Jay Edward,REITZ, Allen B.,PELLETIER, Jeffery Claude,SMITH, Garry Robert,BIAN, Haiyan
申请号：
EP16759303
公开号：
EP3265448A4
申请日:
2016.02.26
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
