MODULATION D'UNE ZONE CIBLE PÉRIODIQUE QUOTIDIENNE DANS LE PROBLÈME DE COMMANDE PRÉDICTIVE BASÉE SUR UN MODÈLE POUR UN PANCRÉAS ARTIFICIEL POUR DES APPLICATIONS AU DIABÈTE TYPE I
DOYLE III, FRANCIS J.,DASSAU, EYAL,GONDHALEKAR, RAVI, L.
申请号：
EP14738072
公开号：
EP2943150A4
申请日:
2014.01.14
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
A controller for an artificial pancreas for automated insulin delivery to patients with type 1 diabetes mellitus (T1DM) that enforces safe insulin delivery throughout both day and night, wherein the controller employs zone model predictive control, whereby real-time optimization, based on a model of a human's insulin response, is utilized to regulate blood glucose levels to a safe zone, and time-dependent zones that smoothly modulate the controller correction based on the time of day, wherein the controller strategically strives to maintain an 80-140 mg/dL glucose zone during the day, a 110-220 mg/dL zone at night, and a smooth transition of 2 hour duration in between.
