An endoscopic reposable surgical clip applier is provided and includes a handle assembly and an endoscopic assembly. The endoscopic assembly is selectively connectable to and in mechanical communication with the handle assembly and includes a shaft assembly. The shaft assembly includes a pair of jaws pivotably and fixedly supported in, and extending from a distal portion of the shaft assembly, a spindle assembly supported within the endoscopic assembly, and a lockout mechanism fixedly supported on the pair of jaws. A distal end of the spindle is operatively engaged with the pair of jaws to effectuate an opening and a closing of the pair of jaws upon an axial translation of the spindle. The lockout mechanism is in selective engagement with the spindle and includes a first position that enables distal advancement of the spindle and a second position that inhibits distal advancement of the spindle.