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DÉRIVÉ À NOYAU À CINQ CHAÎNONS HÉTÉROCYCLIQUE AROMATIQUE AYANT UNE ACTIVITÉ INHIBITRICE DE TRPV4
专利权人:
Shionogi & Co.; Ltd.
发明人:
申请号:
EP13769523.5
公开号:
EP2832731A1
申请日:
2013.03.26
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
The present invention is related to a compound represented by formula (I)wherein R1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted aromatic carbocyclyl, or the like; X is -N(R3)-, -O-, or -S-; Y is =C(R4)-, or =N-; Z is -N(R7)-, -O-, or -S-;R2 is substituted or unsubstituted alkyloxy, or the like, or a group represented by the following formula: -(CR2aR2b)n-R2c, wherein R2a is each independently a hydrogen atom, halogen, or the like; R2b is each independently a hydrogen atom, halogen, or the like; R2a and R2b which are attached to the same carbon atom may be taken together to form oxo, a substituted or unsubstituted non-aromatic carbocycle, or the like; two of R2a which are attached to the adjacent carbon atoms and/or two of R2b which are attached to the adjacent carbon atoms may be taken together to form a bond; R2c is substituted or unsubstituted aromatic carbocyclyl, or the like; n is an integer from 1 to 3;R3 and R7 are each independently a hydrogen atom, substituted or unsubstituted alkyl, or the like;R4 and R5 are each independently a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like;R6 is a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like,or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.
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