METHODS OF REPRODUCING THE CONCENTRATION OF REACTIVE OXYGEN SPECIES IN THE PROSTATE OF A HUMAN HUMAN BEING, PROPHILICALLY TREATING A PROSTATE HUMAN HUMAN HUMAN CANCER POLYAMINE OXIDASE IN THE PROSTATE OF A HUMAN HUMAN BEING, DETERMINING OXIDATIVE STRESS IN HUMAN TISSUE, TREATING CANCER PROSTATE, REPRODUCING THE CONCENTRATION OF OXYGEN DEXYENE AND KIN DEXTENE SPECIES OXIDATIVE FABRIC STRESS OF MALE HUMAN PROSTATE, ORAL PHARMACEUTICAL COMPOSITION, KIT AND REAGENTS TO MEASURE CONCENTRATION OF EX VIVO OR IN VIVO REACTIVE OXYGEN SPECIES, ORGAN OR ORGAN CELL
HIRAK S. BASU,DAWN R. CHURCH,PATRICK M. WOSTER,GEORGE WILDING
申请号：
BRPI0711280
公开号：
BRPI0711280A2
申请日:
2007.05.03
申请国别(地区):
BR
年份:
2012
代理人:
摘要：
METHODS OF REDUCING THE CONCENTRATION OF REACTIVE OXYGEN SPECIES IN THE PRASTATE OF A HUMAN HUMAN BEING, PROPHILICALLY TREATING A PRASTA OF A HUMAN HUMAN HUMAN BEING POLYAMINE OXIDASE IN THE PRASTATE OF A HUMAN HUMAN BEING, DETERMINING HUMAN FABRIC OXIDATIVE STRESS, TREATING CANCER, REDUCING THE CONCENTRATION OF OXYGEN DEXYENE AND HUMAN KINES DE REPRESENTATION OXIDATIVE FABRIC STRESS OF MALE HUMAN PRASTATE, ORAL PHARMACEUTICAL COMPOSITION, AND REAGENT KIT FOR MEASURING CONCENTRATION OF SPECIES OF EXACTIVE REACTIVE OXYGEN IN A CIRCULA OR CIRCULA. N1, N4-bis (buta-1,3-dienyl) butane-1,4-diamine dihydrochloride (also referred to as MDL 72,527 and N, N'-di-2,3-butadienyl-1 dihydrochloride , 4-butanediamine) or salts or solvates thereof, their use as an antioxidant, their use in the prevention and / or treatment of prostate cancer in male humans, and their use in reducing the concentration of reactive oxygen species in Human prostate gland tissue or any other body tissue, and methods of making the compound for the same. Other methods include inhibiting acetyl polyamine oxidase in human prostate tissue or other human body tissue comprising administering a therapeutic amount of N, N1-bis (2,3-butadienyl) -1,4-butanediamine or a salt or solvate. same to human, and a method of determining oxidative stress in human prostate tissue or other human or animal body tissue comprising measuring a fluorescence ratio of 2 ', 7'-dichlorohydrofluorescein diacetate: DNA fluorescence and ex vivo or in vivo hydroetidine dye fluorescence.MÉTODOS DE REDUZIR A CONCENTRAÇçO DE ESPÉCIES DE OXIGÊNIO REATIVO NA PRàSTATA DE UM SER HUMANO DO SEXO MASCULINO, DE TRATAR PROFILATICAMENTE CÂNCER DA PRàSTATA DE UM SER HUMANO DO SEXO MASCULINO, DE TRATAR CÂNCER NA PRàSTATA DE UM SER HUMANO DO SEXO MASCULINO, DE INIBIR ACETIL POLIAMINA OXIDASE NA PRàSTATA DE UM SER HUMANO DO SEXO MASCULINO, DE DETERMINAR ESTRESSE OXIDATIVO EM TECIDO HUMANO, DE TRATAR CÂNCER NA PRàSTATA DE UM CACHORRO, DE REDUZIR A CONCENTR
