FERNAND LBRIE,SHANKAR MOHAN SINGH,RICHARD LABRECQUE,LIVIU C. CIOVANU
申请号：
ARP140104827
公开号：
AR098887A1
申请日:
2014.12.19
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
Compounds or salts used to treat or reduce human pathogenic diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovary syndrome, acne,Boiling, seborrea, male aloe, male baldness, muscle atrophy and weakness, scabies, male allergy, erectile dysfunction, female sexual dysfunction and osteoporosis. These products can be designed with acceptable drug diluents or transporters, or in other ways to produce a drug dose. Joint publicity has also been carried out with other active pharmaceutical preparations. Claim 1: a formula compound (1), wherein n is an integer from 0 to 6； m is an integer from 0 to 1； J is an independent direct link, or from - or-- I...-CH₂-,- yes.-So...-SO₂-,- en...-Chris...-C (R) - y -NR -R749195 and r74955 were selected independently from group A of hydrogen and halogen-oc8323a；C₁₋₃ alkyl, C₂₋₃ alkenyl, nitrile, trifluoromethyl, amide, amine and alkylsulfone； wherein R¹ is selected from the group consisting of hydrogen, halogen and C₁₋₃ alkyl； wherein R² is selected from the group consisting of hydrogen, halogen, -OCH₃,-SCH₃,alkylsulfoxide, alkylsulfone, nitrile, -NO₂,C₁₋₃ alkyl and trifluoromethyl； wherein R³ is selected from the group consisting of halogen, nitrile, -COCH₃,-SO₂CH₃ and -NO₂；wherein R⁴ and R⁵ are independently selected from the group consisting of hydrogen, C₁₋₆ alkyl, halogen, -OCH₃,-SCH₃,alkylsulfoxide, alkylsulfone, nitrile, -NO₂ and trifluoromethyl； or R⁴ and R⁵ together form a cycle that optionally contains a heteroatom selected from the group consisting of nitrogen, oxygen and sulfur； wherein R⁶ and R⁷ are independently selected from the group consisting of hydrogen and C₁₋₆ alkyl or R⁶ and R⁷ together form a cycle that optionally contains a heteroatom selected from the group consisting of nitrogen, oxygen and sulfur； wherein W is selected from the group consisting of oxygen and sulfur； where G¹,G,G3,g. 83088 and g83099 were selected independently from the carbon, thyroid, nitrogen and nitrogen oxides grou
