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Substituted pyrrolidines as ROS tyrosine kinase inhibitors
专利权人:
NIPPON SHINYAKU CO.; LTD.
发明人:
Katsutoshi Hori,Hiroki Hayase,Tomohiro Terada
申请号:
US14402198
公开号:
US09580413B2
申请日:
2013.05.29
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The main purpose of the invention is to provide a novel aromatic heterocyclic derivative or a pharmaceutically acceptable salt thereof. Examples of the invention include aromatic heterocyclic derivatives represented by general formula [1] and pharmaceutically acceptable salts thereof.In formula [1]: R1 represents phenyl optionally substituted with one or two groups selected from the group consisting of halogens, as well as alkyls and alkoxys optionally substituted by halogens; R2 represents hydrogen, an alkyl, cycloalkyl, or alkoxy optionally substituted by a halogen, or a heteroaryl optionally substituted by an alkyl; X represents CR3, and Y represents N or CR4, or X represents N, and Y represents CR4; and Z represents CR5 or N.
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