A tissue engageable suture having antimicrobial properties is provided. The suture includes a plurality of thread members. The thread members include a plurality of structural thread members having a structural portion and an antimicrobial portion. The thread members also include a plurality of adhesive thread members. The plurality of structural thread members and the plurality of adhesive thread members are woven together to form a multiple thread-containing cabled suture wherein the adhesive thread members bond the structural thread members within the cabled structure.