NISHINO, TAITO,MIYAJI, KATSUAKI,IWAMOTO, SHUNSUKE,MIKASHIMA, TAKUMI,SARUHASHI, KOICHIRO,KISHIKAWA, YO
申请号：
CA2819215
公开号：
CA2819215C
申请日:
2011.12.01
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
Novel therapeutic agents for myeloma are provided.A therapeutic agent for multiple myeloma containing a pyrazole compoundrepresented by the formula (1):(see formula 1)wherein R1 is C1 -C6 alkyl, C1 -C6 alkyl substituted with R17, C1 -C6haloalkyl, phenyl,phenyl substituted with a R11' s or the like, R2 is a hydrogen atom, C1 -C6alkyl, phenylor phenyl optionally substituted with e R21' s or the like, R3 is a hydrogenatom or thelike, X is a single bond or -(CR6 R7 )n -, each of R4 and R5 is independentlyC1 -C6 alkylor the like, R6 and R7 are hydrogen atoms or C1 -C6 alkyl, R8 is phenyl,phenyloptionally substituted with k R81's or the like, a tautomer of the compound orapharmaceutically acceptable salt or solvate thereof, as an active ingredient.
