Siddhartha Banerjee,Navnit H. Shah,Gaurang Patel,Murali Mohan Bommana,Ashish Chatterji,Anita Kumar,Petra Inbar,Furong Liu,Srinivas Kone,Priti L. Jagani,Wantanee Phuapradit
申请号：
US15770021
公开号：
US20180303757A1
申请日:
2016.10.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present technology relates to an extended-release solid oral pharmaceutical composition, comprising a cured blend of a melt-extruded first component and a second component, wherein the melt-extruded first component comprises a therapeutically effective amount of an opioid or a pharmaceutically acceptable salt thereof, at least one PEO polymer, and a stabilizing agent； and the second component comprises at least one PEO polymer and an oxidative stabilizing agent. The extended-release pharmaceutical compositions of the present technology provide crush-resistant and abuse-deterrent formulations featuring enhanced heat stability, resistance to drug segregation, and resistance to alcohol-induced dose dumping.
