Disclosed is a melt-extruded abuse-resistant drug delivery composition for delivering a drug that has potential for dose dumping in alcohol (i.e., reduced drug-alcohol interaction), comprising: (a) A drug having potential for dose dumping in alcohol selected from a group consisting of verapamil, gammahydroxybutyrate, and flunitrazepam； and (b) A matrix having a polymer, copolymer or combinations thereof, wherein a monomer is natrium-alignate. Further disclosed is the use of said composition in preparing a medicament.
