This invention is directed towards a modular sealable enclosure for deployment inside a space such as a hospital room, ward or unit, to reduce the spread of Hospital Acquired Infections (HAIs) and to facilitate decontamination of an area known or thought to contain the pathogens which cause HAIs. The modular sealable enclosure comprises a plurality of side panels and sealing means to seal one side panel to one or more other side panels to form an enclosure with at least one side wall, a ceiling and a floor. The enclosure further comprises at least one opening provided in at least one side wall and at least one closure for selectively covering and sealing the at least one opening. The at least one closure comprises a blind and clamping means for sealing the blind to the side wall. The enclosure further comprises means to connect the enclosure to an adjacent enclosure.