THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE; INC.
发明人:
DALY, MICHAEL J.,GAIDAMAKOVA, ELENA K.
申请号：
CA2797716
公开号：
CA2797716C
申请日:
2011.04.29
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention provides methods of producing vaccines directed againstmicroorganisms, with the methods comprisingculturing, harvesting and/or suspending the microorganism in the presence of aradiation-protective composition and irradiatingthe bacteria or viruses with a dose of radiation sufficient to render themicroorganism replication-deficient and/or non-infective.The radiation- protective compositions used in the methods of the presentinvention comprise at least one nucleoside, atleast one antioxidant and at least one small peptide. The invention alsoprovides methods of rendering bacteria in culture resistantto ionizing radiation (IR), with these methods comprising culturing thebacteria in the presence of a radiation-protective composition.
