Kallanthottathil G. Rajeev,Muthiah Manoharan,Eric E. Swayze,Thazha P. Prakash
申请号：
US13638891
公开号：
US09102938B2
申请日:
2011.03.31
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides nucleosides of formula (1) and oligonucleotides comprising at least on nucleoside of formula (2):Formula (1) and Formula (2). Another aspect of the invention relates to a method of inhibiting the expression of a gene in call, the method comprising (a) contacting an oligonucleotide of the invention with the cell and (b) maintaining the cell from step (a) for a time sufficient to obtain degradation of the mRNA of the target gene.
