The present disclosure provides isolated monoclonal antibodies that specifically bind to CXCR4 with high affinity, particularly human monoclonal antibodies. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting CXCR4, as well as methods for treating various cancers, inflammatory disorders and HIV infection using an anti-CXCR4 antibody of this disclosure.本發明提供具高親和性與CXCR4專一性結合之經分離之單株抗體，特別是人單株抗體。本發明亦提供編碼本發明之抗體的核酸分子、表現載體、宿主細胞及用於表現本發明之抗體的方法。本發明亦提供包含本發明之抗體的免疫偶聯物、雙特異性分子及醫藥組成物。本發明亦提供偵測CXCR4之方法及利用本發明之抗CXCR4抗體以治療各種癌症、發炎性疾病及HIV感染之方法。
