A system for changing pressure in one or more tires of a self-propelled agricultural machine according to a load differential determined using load sensors on opposing locations of the machine. A load differential may be caused by a disproportionate distribution of forces and/or weight on the machine. Load sensors proximal to the tires may allow determining corresponding loads on the tires and, in turn, the load differential. As a result, tires experiencing greater loads may be inflated, whereas tires experiencing lesser loads may be deflated. In addition, a Human Machine Interface (HMI) may be provided in the operator cab to allow an operator to have further control over tire inflation on the fly while operating the machine.