The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.本發明係關於一種與分子支架共價結合使得二或多個胜肽環介於與該支架的連接點之間的多肽。特定而言，本發明記載的胜肽為Nectin-4的高親和性結合劑。本發明另包括含有結合至一或多效應物及/或官能基的胜肽的藥物結合物、包括該胜肽配體或藥物結合物之醫藥組成物、以及該胜肽配體和藥物結合物用於預防、抑制或治療Nectin-4介導的疾病或病症之用途。
