Chromosomal modification involving the induction of double-stranded DNA cleavage and homologous recombination at the cleavage site

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专利权人:

发明人:

Andre Choulika,Richard C. Mulligan

申请号：

US14550463

公开号：

US09458439B2

申请日:

2014.11.21

申请国别(地区):

US

年份:

2016

代理人:

摘要：

Methods of modifying, repairing, attenuating and inactivating a gene or other chromosomal DNA in a cell are disclosed. Also disclosed are methods of treating or prophylaxis of genetic disease in an individual in need thereof. Further disclosed are chimeric restriction endonucleases.

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