This is the process for preparation of a novel base material for manufacturing cream, comprising of cooling and soothing agent on the skin Ghee 12%, Coconut oil (Cocos nucifera) 12%, Water 65%, and mixture of Cetyl alcohol, Laxemul (Glyceryl stearate+PEG 100 stearate) and vegetable Glycerol in ratio of 4:5:1 respectively totaling 10%. Freeze dried water extracts of herbs, Cassia tora 0.005%, Centratherum anthelminticum 0.005% and Melia azadirachta 0.005%, Neem kernel oil 0.48%, Rose oil 0.02%. To investigate the effect of herbal compositions suspended in a cream based on novel vehicle Ghee (clarified butter) and develop natural cream useful for treatment of any sort of itchy and or infected skin, impetigo, children eczema, psoriasis, acne, and athlete's foot. The base of the cream is useful to those individuals who react to conventional creams containing chemicals. Theme chemicals are proven skin sensitizers such as Chlorocresol, cetosteryl alcohol, Parabens etc.