Thaler, Florian,David, Cibele Maria Sabido,Maestroni, Sara,Raveglia, Luca Francesco,Salvati, Patricia
申请号：
NO20062231
公开号：
NO337679B1
申请日:
2006.05.18
申请国别(地区):
NO
年份:
2016
代理人:
摘要：
This invention is related to compounds and use of 3-aminopyrrolidone derivatives and analogues of the following general formula (I) wherein m is an integer from 1 to 3 X is methylene, oxygen, sulphur or a NR<6> group R<1> is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups R<2>, R<3> are independently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups R<4>, R<5>, R<6> are independently hydrogen or C1-C6 alkyl and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.
