This invention is related to novel cyclopentyl derivatives of the followinggeneral Formula (I), wherein X is methylene, oxygen, sulphur or a NR7 group；R1 is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8alkynylene chain, optionally substituted with CF3, phenyl, phenoxy ornaphthyl, the aromatic rings optionally substituted by one or more C1-C4alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups； R2, R3 areindependently hydrogen, a C1-C3 alkyl chain, halogen, trifluoromethyl, hydroxyor C1-C4 alkoxy groups； R4, R5, R6, R7 are independently hydrogen or C1-C6alkyl； and the pharmaceutically acceptable salts thereof that are active assodium and/or calcium channel modulators and therefor useful in preventing,alleviating and curing a wide range of pathologies, including, but not limitedto, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic,urologic, metabolic and gastrointestinal diseases, where the above mechanismshave been described as playing a pathological role.
