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Bis(styryl)pyrimidine or bis(styryl)benzene compounds, pharmaceutically acceptable salts thereof, preparation method thereof, and pharmaceutical composition for prevention or treatment of diseases featuring amyloids comprising the same as an active ingredient
专利权人:
Kye Jung Shin
发明人:
Kye Jung Shin,Eun Joo Roh,Yun Suk Lee
申请号:
US12429552
公开号:
US08410116B2
申请日:
2009.04.24
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Disclosed are bis(styryl)pyrimidine or bis(styryl)benzene compounds, represented by Chemical Formula 1, pharmaceutically acceptable salts, a method for preparing the same, and a pharmaceutical composition for the prevention and treatment of amyloidosis-associated diseases, comprising the same as an active ingredient. Having the ability to inhibit the deposition of beta amyloid and to reduce the toxicity of beta amyloid, the derivatives can improve learning and memory and can be useful in the prevention and treatment of amyloidosis-associated diseases.(wherein R1, R2, R3 and X are as defined in the specification).
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