(57) for oral administration, relates to a pharmaceutical formulation and a formulation component which acts on the release of the active agent and one active agent, the formulation thereof, [Abstract] The present invention may be used for the rapid release in at least one particular , in vitro release rate of the formulation by Ph. Eur. paddle test indicates an average value of greater than 40% after 1 hour on the other hand, in vitro release rate is shown an average value of 80 wt% at 4 hours after including opioid analgesics at least one as an active substance that is formulated proportionally for delayed release. Salts, the invention relates to pharmaceutical formulations comprising tramadol hydrochloride particularly applicable tramadol or pharmaceutically tramadol as active substances in particular.本発明は、特に経口投与のための、少なくとも1つの活性物質と活性物質の放出に作用する製剤成分とを有する医薬製剤に関し、その製剤は、一方で急速放出のために、他方でPh. Eur. パドル試験による製剤のin vitro放出率が1時間後に40重量%を超える平均値をしめし、in vitro放出率が4時間後でも80重量%未満の平均値を示すように遅延放出のために比例的に製剤化される活性物質として少なくとも1つのオピオイド鎮痛薬を含む。本発明は、特に活性物質としてトラマドール又は製薬上適用可能なトラマドールの塩、特に塩酸トラマドールを含む医薬製剤に関する。
