WYETH LLC;WISCONSIN ALUMNI RESEARCH FOUNDATION;THE JOHNS HOPKINS UNIVERSITY
发明人:
申请号：
IL16665105
公开号：
IL166651A
申请日:
2005.02.02
申请国别(地区):
IL
年份:
2013
代理人:
摘要：
The invention provides an in vitro method of decreasing myostatin activation. The method comprises contacting a sample comprising a latent myostatin complex comprising a myostatin pro peptide and a myostatin C-terminal fragment, and a metalloprotease that can cleave the myostatin pro peptide, with an agent that decreases proteolytic cleavage of the pro peptide by the metalloprotease, thereby decreasing myostatin activation. The metalloprotease is a bone morphogenic protein-1/tolloid (BMP-1/TLD) family member and the agent is a peptide selected from the group consisting of SEQ ID NOS: 9-23. Also provided is such an agent for use in decreasing myostatin activation in a subj ect.
