Combining Radioimmunotherapy and Antibody-Drug Conjugates for Improved Cancer Therapy

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专利权人:

发明人:

Serengulam V. Govindan,David M. Goldenberg

申请号：

US14029165

公开号：

US20140044640A1

申请日:

2013.09.17

申请国别(地区):

US

年份:

2014

代理人:

摘要：

Described herein are compositions and methods of use of radionuclide-antibody conjugates (for RAIT) and drug-antibody conjugates (ADC). The combination of RAIT and ADC was more efficacious than either RAIT alone, ADC alone, or the sum of effects of RAIT and ADC. The unexpected synergy resulted in decreased tumor growth rate and increased survival, with a high incidence of tumor-free survival in Capan-1 human pancreatic cancer xenografts in nude mice.

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