The present invention is directed to the compounds of formula wherein R1 to R5 have the significances given herein, to processes for the manufacture of said compounds as well as medicaments containing said compounds. The compounds according to this invention show anti-proliferative and differentiation-inducing activity and are thus useful for the treatment of diseases such as cancer in humans or animals.本發明係關於下式之化合物；(I)，；其中R1至R5具有本文中所給之意義，關於製造該等化合物以及含有該等化合物之藥劑之方法。本發明化合物顯示抗增殖及誘導分化活性，因此可用於治療人類或動物諸如癌症等疾病。
