Barf Tjeerd A.,Jans Christiaan Gerardus Johannes Maria,Man De Adrianus Petrus Antonius,Oubrie Arthur A.,Raaijmakers Hans C.a.,Rewinkel Johannes Bernardus Maria,Sterrenburg Jan-Gerard,Wijkmans Jacobus
申请号：
NZ71611012
公开号：
NZ716110A
申请日:
2012.07.11
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Provided are 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides of the general formula (I), wherein the variables are as defined in the specification. Examples of the compounds include (S)-4-(3-(1-Acryloylpyrrolidin-2-y1)-8-aminoimidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide and (S)-4-(8-amino-3-(1-but-2-ynoylpyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-phenylpyridin-2-yl)benzamide. The compounds are inhibitors of Brutons Tyrosine Kinase (Btk). The compounds may be used to treat immune, autoimmune, inflammatory, infectious, bone resorption and proliferative diseases mediated by this kinase.
