BARF TJEERD A.,JANS CHRISTIAAN GERARDUS JOHANNES MARIA,MAN DE ADRIANUS PETRUS ANTONIUS,OUBRIE ARTHUR A.,RAAIJMAKERS HANS C.A.,REWINKEL JOHANNES BERNARDUS MARIA,STERRENBURG JAN-GERARD,WIJKMANS JACOBUS
申请号：
NZ62008512
公开号：
NZ620085A
申请日:
2012.07.11
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Provided are 4-imidazopyridazin-1-yl-benzamides and 4-imidazotriazin-1-yl-benzamides of the general formula (I), wherein the variables are as defined in the specification. Examples of the compounds include (S)-4-(3-(1-Acryloylpyrrolidin-2-y1)-8-aminoimidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide and (S)-4-(8-amino-3-(1-but-2-ynoylpyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-phenylpyridin-2-yl)benzamide. The compounds are inhibitors of Brutons Tyrosine Kinase (Btk). The compounds may be used to treat immune, autoimmune, inflammatory, infectious, bone resorption and proliferative diseases mediated by this kinase.
