The present invention relates to the use of a composition comprising short-chain peptide in preventing/treating dry eye syndrome. The composition of present invention comprises short-chain peptides having 5~10 amino acids and exhibiting effects on promoting corneal repair, increasing eye humidity and improving dry eye disease.本發明係關於一種短鏈胜肽組合物於預防或治療乾眼症之應用。本發明之短鏈胜肽組合物包含一由5~10個胺基酸組成之短鏈胜肽,具有促進角膜修復、增加眼睛濕度及改善乾眼症的功效。