PRICE, STEPHEN,HEALD, ROBERT,HEWITT, JOANNE MARY FRANCES,LEE, WENDY,ZAK, MARK E.
申请号：
PE0003812013
公开号：
PE12102013A1
申请日:
2008.12.18
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
Relates to compounds of formula I: Z1 is where R1 is H, CR1, CR2 is r1\u00b4es h Z2, Z3 is Cr3 or N R2 and R3 are independently H or Halogen R4 is h and - C (o) - W, where W is (i) wherein R5 is or11\u00b4 X1 is H, alkyl -, where is r11\u00b4 (C1 C12) x4 (r6), where r6\u00b4 is Halogen, among others Is H or alkyl, Halo (C1 - C6), p is an integer from 0 to 2.Preferred compounds are: (2-hydroxyethoxy) - amide acid 5 - (2 - 4 - Fluorine - yodofenilamino) imidazo [1,5-a] pyridin - 6 - carboxylic acid (S) - 5 - (4-bromo-2 - fluorfenilamino) - N - (2 - hydroxy propoxy) imidazo [pirazin 1,5-a] - 6 - carboxamide among others.These compounds are inhibitors of MEK kinase activity, being useful for the treatment of Cancer and inflammatory diseases such as rheumatoid arthritisSE REFIERE A COMPUESTOS DE FORMULA I DONDE: Z1 ES CR1 R1 ES H R1´ES H Z2 ES CR2 Z3 ES CR3 O N R2 Y R3 SON INDEPENDIENTEMENTE H O HALOGENO R4 ES H Y ES W-C(O)-, DONDE W ES (i), EN DONDE R5 ES H, X1 ES -OR11´, DONDE R11´ ES ALQUILO (C1-C12) X4 ES (a),DONDE R6 ES HALOGENO, ENTRE OTROS R6´ES H, HALO O ALQUILO (C1-C6) p ES UN ENTERO DE 0 A 2. SON COMPUESTOS PREFERIDOS: (2-HIDROXIETOXI)-AMIDA DEL ACIDO 5-(2-FLUOR-4-YODOFENILAMINO)-IMIDAZO[1,5-a]PIRIDIN-6-CARBOXILICO (S)-5-(4-BROMO-2-FLUORFENILAMINO)-N-(2-HIDROXI-PROPOXI)IMIDAZO[1,5-a]PIRAZIN-6-CARBOXAMIDA ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVIDAD DE MEK QUINASA, SIENDO UTILES PARA EL TRATAMIENTO DE CANCER Y ENFERMEDADES INFLAMATORIAS TALES COMO ARTRITIS REUMATOIDEA
