National Institute of Biological Sciences; Beijing
发明人:
Zhiyuan Zhang,Xiaodong Wang,Shaoqiang Huang,Xian Jiang,Li Li,Zhaolan Zhang,Jianguang Han
申请号:
US16248755
公开号:
US20190152960A1
申请日:
2019.01.15
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The invention provides compounds that are inhibitors or covalent modifiers of succinate dehydrogenase subunit B (SDHB) and/or inhibitors of apoptosis, and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition.