The present invention relates to engineered &gamma；&delta； T-cell(s) and methods for using the same as a therapeutic with a potent and selective ability to target an antigen of choice. Engineered &gamma；&delta； T-cells of the disclosure are useful in the treatment of various cancers, infectious diseases, and immune disorders. Also disclosed are methods for expanding engineered and non-engineered &gamma；&delta； T-cell(s) populations to therapeutically useful quantities. An engineered &gamma；&delta； T-cell of the disclosure can be a universal donor, and can be administered to a subject with any MHC haplotype.
