THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人:
BRESLOW, RONALD,MARKS, PAUL, A.
申请号：
EP12838935
公开号：
EP2763531A4
申请日:
2012.10.03
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
This invention provides a compound having the structure: wherein R1 is H, halogen, &mdashNR5R6, &mdashNR5&mdashC(&boxHO)&mdashR6, &mdashNH&mdashC(&boxHO)&mdashOR7, &mdashOR7, &mdashNO2, &mdashCN, &mdashSR7, &mdashSO2R7, &mdashCO2R7, CF3, &mdashSOR7, &mdashPOR7, &mdashC(&boxHS)R7, &mdashC(&boxHO)&mdashNR5R6, &mdashCH2&mdashC(&boxHO)&mdashNR5R6, &mdashC(&boxHNR5)R6, &mdashP(&boxHO)(OR5)(OR6), &mdashP(OR5)(OR6), &mdashC(&boxHS)R7, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, aryl, heteroaryl, or heterocyclyl, wherein R5, R6, and R7 and are each, independently, H, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl m is an integer from 0 to 2 R2 and R3 are each, independently, H, halogen, &mdashNH2, &mdashCX3, &mdashC(&boxHO)OR8, C(&boxHO)R8, &mdashC(&boxHO)NR9R10, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, heteroalkyl, aryl, heteroaryl, or heterocyclyl wherein X is Cl, Br, or F R8, R9 and R10 are each, independently, H, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl Q is &mdashAr1&mdashZ&mdash or &mdashZ&mdashAr1&mdashZ&mdash, wherein Ar1 is aryl or heteroaryl and each occurrence of Z is independently present or absent, and when present is &mdashO&mdash, &mdashS&mdash, &mdashCH2&mdash, &mdashC(O)&mdash&mdashNH&mdash, &mdashNH&mdashNH&mdash, &mdashNHC(&boxHO)&mdash, &mdashC(&boxHO)NH&mdash, &mdashNHC(&boxHO)CH2NH&mdash, &mdashNHC(&boxHO)CH2C(&boxHO)&mdash, &mdashN(OH)&mdash, &mdashCH2CH2&mdash or &mdashNHC(&boxHO)CH&boxHCH&mdash and R4 is alkyl, &mdashOR11 or &mdashNH&mdashOR11, wherein R11 is H, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, aryl, heteroaryl, or heterocyclyl, and when Q is &mdashAr1&mdashZ&mdash, Z is absent, Ar1 is phenyl, R2 and R3 are H, n=1, and R4 is &mdashNHOH, then R1 is other than carbazole, tetrahydro-&bgr-carboline, tetrahydro-&gamma-carboline, &mdashC(&boxHO)&mdashNR5R6 and &mdashNR5&mdashC(&boxHO)&mdashR6, wherein one of R5 or R6 is quinoline a
