Various methods and systems are provided for ultrasonically scanning a tissue sample using a hand-held automated ultrasound system. In one example, a system for ultrasonically scanning a tissue sample includes a hand-held ultrasound probe including a housing and a transducer module comprising a transducer array of transducer elements, one or more position sensors coupled within the housing, and a controller. The controller is configured to generate one or more images based on ultrasound data acquired by the transducer module and further based on position sensor data collected by the one or more position sensors.