Dean, Nicholas M.,Krochmal, Lincoln,Hardee, Gregory,Foulkes, J. Gordon,O'Donnell, Niall,Young, Leroy,Jewell, Mark,ODonnell, Niall
申请号：
AU2012212110
公开号：
AU2012212110A1
申请日:
2012.02.02
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.
