Nicholas M. Dean;Leroy Young;Gregory Hardee;Lincoln Krochmal;Niall O'Donnell;Mark Jewell;J. Gordon Foulkes
发明人:
Nicholas M. Dean,Lincoln Krochmal,Gregory Hardee,J. Gordon Foulkes,Niall O'Donnell,Leroy Young,Mark Jewell
申请号：
US16136750
公开号：
US20200190521A1
申请日:
2019.09.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
This invention provides methods of preventing formation of, or treating, fibrotic lesions, including skin scars such as keloids and hypertrophic scars which comprise administering to the subject by one or more injection a compound which comprises a modified oligonucleotide, such as a modified antisense oligonucleotide, siRNA, or oligodeoxyribonucleotide, which inhibits expression of protein involved in fibrosis. Dosing of the antisense using an intradermal threading technique is also described.
