Alan T. Remaley,Stephen J. Demosky,John A. Stonik,Marcelo J. A. Amar,Edward B. Neufeld,H. Bryan Brewer,Fairwell Thomas
申请号：
US12766761
公开号：
US08148323B2
申请日:
2010.04.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed herein are peptides or peptide analogs with multiple amphipathic α-helical domains that promote lipid efflux from cells via an ABCA1-dependent pathway. Also provided herein are methods of using multi-domain amphipathic α-helical peptides or peptide analogs to treat or inhibit dyslipidemic disorders. Methods for identifying non-cytotoxic peptides that promote ABCA1-dependent lipid efflux from cells are also disclosed herein.
