THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO;UNIVERSITY HEALTH NETWORK
发明人:
LEONG, LIANG WEY,SANTERRE, PAUL,SHARIFPOOR, SOROR
申请号：
CA2979429
公开号：
CA2979429C
申请日:
2017.02.16
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
A soft tissue filler comprising a biodegradableamino-acid derived polycarbonate-urethanes and methodsof repairing soft tissue defects are provided. The biodegradablesoft tissue filler comprises a porous scaffold that isthe reaction product of: a) a divinyl oligomer componentthat comprises a carbonate-derived divinyl oligomer that isthe reaction product of a lysine-derived diisocyanate, a vinylcoupling agent, and a polycarbonate and, optionally, anether-derived divinyl oligomer, wherein the ether-deriveddivinyl oligomer is the reaction product of a lysine-deriveddiisocyanate, a vinyl coupling agent, and an ether； b) at leastone anionic monomer； and c) at least one hydrophobicmonomer. The molar ratio of (a) : (b+c) is between about1>；=21 and about 1:30, the soft tissue filler has a porosity of>； 75 %； and a compressive moduli of between about 1 kPaand about 50 kPa.
