Akihiro Hashimoto,Atul Agarwal,Avinash Phadke,CUIXIAN LIU,Dawei Chen,Godwin Pais,Ha Young Kim,Milind Deshpande,SUOMING ZHANG,Shouming Li,Venkat Gadhachanda,Xiangzhu Wang
申请号：
BRPI0922912
公开号：
BRPI0922912A8
申请日:
2009.12.10
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The invention provides 4-amino-4-oxobutanoyl peptides of Formula I and the pharmaceutically salts and hydrates thereof. The variables R, R1, R6-R8, R16, R18, R19, M, n, T, Y, and Z are defined herein. Certain compounds of Formula I are useful as antiviral agents. The 4-amino-4-oxobutanoyl peptides disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more 4-amino-4-oxobutanoyl peptides and one or more pharmaceutically acceptable carriers. Such pharmaceutical compositions may contain a 4-amino-4-oxobutanoyl peptides as the only active agent or may contain a combination of a 4-amino-4-oxobutanoyl peptides and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections.
