MICKLE, Travis,GUENTHER, Sven,BERA, Sanjib,BERA, Bindu,KANSKI, Jaroslaw,MARTIN, Andrea K.
申请号：
PH12017500963
公开号：
PH12017500963A1
申请日:
2017.05.25
申请国别(地区):
PH
年份:
2017
代理人:
摘要：
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxycodone (4,5-a-epoxy-14-hydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxycodone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxycodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
