A scalpel handle is uniquely shaped to provide gripping comfort while performing multiple styles of hand holds for long periods of time. There are textured surfaces to prevent slippage of fingers. The slope of the handle itself conforms to the natural curvature of the human hand. Embodiments achieve the above objectives by providing an ergonomic handle for precision surgical and dental use, among others. In some embodiments it is wider across the top surface as opposed to typical flat scalpels to provide a more efficient surface for applying pressure downwards during cutting procedures. It is also curved down and away from the blade/tool attachment area to conform to the pocket of the human hand. This ergonomically improved handle conforms to natural human hand shape, allows for better grip under stress, increased tactile feedback and cutting efficiency, and a comfortable grip during long term usage.