PROBLEM TO BE SOLVED: To provide a novel single strand nucleic acid molecule which can inhibit the activity of a target RNAi molecule, and a novel activity inhibition method for a target RNAi molecule using the single strand nucleic acid molecule.SOLUTION: The present invention provides a single strand nucleic acid molecule that bonds to a target RNAi molecule in two regions of first and second target nucleic acid complementary regions, and an activity inhibition method for a target RNAi molecule using the molecule.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2017,JPO&INPIT【課題】標的RNAi分子の活性を阻害することができる新規な一本鎖核酸分子、及び該一本鎖核酸分子を用いた標的RNAi分子の新規な活性抑制方法を提供することである。【解決手段】標的RNAi分子に対して、第1及び第2標的核酸相補領域の2領域で結合する一本鎖核酸分子、及び該分子を用いる標的RNAi分子の活性阻害方法。【選択図】図1