Embodiments of piscicide formulations are disclosed. A piscicide composition includes a first bead, comprising: about 0.5% to 75% by weight of a primary toxin； and an effective amount of a continuous phase to form the primary toxin into a toxin bead； and a second bead, comprising: about 1% to 85% by weight of a solubilizing agent； and an effective amount of a continuous phase to form the solubilizing agent into a solubilizing bead.
