Disclosed is a composition for transdermal delivery of botulinum toxin comprising: · botulinum toxin and · a sialoprotein adhesion molecule wherein the sialoprote in adhesion molecule forms a non-covalent complex with the botulinum toxin and wherein the sialoprotein adhesion molecule is present in said composition in an amount from 0.1 ng to 1 mg per unit of botulinum toxin, inclusive. Further disclosed is the use of the composition as defined above in the preparation of a medicament for treating a condition by transdermal administration to a subject to intact skin, said condition selected from the group consisting of muscular spasm, clinical or subjective hyperhidrosis, acne, pain, clinical or subj ective dystonia, hypersecretion, wrinkles, and undesired immune response.
