Disclosed herein are methods for the topical treatment of inflammation of the skin and mucosa by applying a pharmaceutical composition including a protein or peptide that blocks the Kv1.3 potassium channel. The proteins and peptides can include an ShK-based protein and peptide.本發明係關於藉由施用包含阻斷Kv1.3鉀通道之蛋白質或肽之醫藥組合物來局部治療皮膚及黏膜發炎之方法。該等蛋白質及肽可包括基於ShK之蛋白質及肽。