The present invention belongs to the field of medicinal chemistry, specifically, a compound having an alkynyl heteroaromatic ring structure or a pharmaceutically acceptable salt, stereoisomer, N-oxide, solvate or prodrug thereof, and these It relates to pharmaceutical compositions containing compounds and the application of these compounds or compositions in pharmaceutical preparations. The compounds of the present invention or pharmaceutically acceptable salts, stereoisomers, N-oxides, solvates or prodrugs thereof and pharmaceutical compositions containing them have good antitumor activity. 2本発明は医薬化学分野に属し、具体的にはアルキニルへテロ芳香環構造を有する化合物又はその薬学的に許容可能な塩、立体異性体、N-オキシド、溶媒和物又はプロドラッグ、並びにこれらの化合物を含有する薬剤組成物およびこれらの化合物又は組成物の薬剤調製における応用に関する。本発明の化合物又はその薬学的に許容可能な塩、立体異性体、N-オキシド、溶媒和物又はプロドラッグ、及びそれらを含む薬剤組成物は良好な抗腫瘍活性を有する。2
