Provided herein is an ophthalmic composition. In some embodiments, the ophthalmic composition includes a low concentration of an ophthalmic agent for treatment of an ophthalmic disorder or condition; and an ophthalmically acceptable carrier, wherein the ophthalmic agent is distributed with substantial uniformity throughout the ophthalmically acceptable carrier. Further disclosed herein include an ophthalmic composition including a low concentration of an ophthalmic agent and deuterated water. Also disclosed herein are methods of arresting or preventing myopia development by administering to an eye of an individual in need thereof an effective amount of an ophthalmic composition as described herein.本文提供眼用組合物。在一些實施例中,該眼用組合物包括低濃度之用於治療眼病症或病況之眼用劑;及眼科上可接受之載劑,其中該眼用劑以實質均勻性分佈遍於該眼科上可接受之載劑之中。本文進一步揭示包括眼用組合物,其包括低濃度之眼用劑及氘化水。本文亦揭示藉由向有需要之個體眼睛投與有效量之如本文所述之眼用組合物來停止或預防近視發展之方法。