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Compositions comprising the fibroblast-free dermal matrix and biocompatible polymers and methods for preparing the same
专利权人:
(주)시지바이오
发明人:
박희준,유현승,한진욱,이지혜,장학수,이선이
申请号:
KR1020197037462
公开号:
KR1020200008602A
申请日:
2018.04.27
申请国别(地区):
KR
年份:
2020
代理人:
摘要:
The present invention relates to a composition comprising a human-derived acellular dermal matrix and gelatin, and more particularly, the degree of change in crosslinking, viscoelasticity, hardening and / or extrusion force values after sterilization of the fibrous acellular dermal matrix and gelatin composition. Is 30% or less, preferably 20% or less, and most preferably 10% or less relative to the value before sterilization, and relates to a composition, a method for preparing the same, and a sheet production using the same. The wound coating paste of the present invention can be easily applied to a difficult or topical area where a conventional sheet-shaped dermal matrix is difficult to apply, and is a ready-to-use product that can be used immediately and is easy to use and has a serious degree of wounding. Quick cure without surgery In addition, it is excellent in the stability of physical properties even during long-term or low temperature storage, and when applied to a topical area, the applicability is soft and excellent adhesion. Accordingly, it is possible to effectively treat the wound site by protecting the wound site from external contaminants and maintaining a humid environment. In addition, the wound coating sheet according to the present invention has excellent bioadhesive properties and does not release the polymer structure well even in a long hydration (rehydration) process, it is excellent in morphology maintenance during the professional procedure. In addition, the sheet can adjust the width, length and thickness size required by the wound site or surgical characteristics can be improved quality of the wound treatment.본 발명은 인체 유래 무세포 진피 기질 및 젤라틴을 포함하는 조성물에 관한 것으로, 보다 자세하게는 섬유화된 무세포 진피 기질과 젤라틴 조성물이 멸균 후 가교도, 점탄성, 경화도 및/또는 압출력 값의 변화도가 멸균 전 값에 비해 30% 이하, 바람직하게는 20% 이하, 가장 바람직하게는 10% 이하인 것을 특징으로 하는 조성물, 이의 제조방법 및 이를 이용한 시트 제조에 관한 것이다. 본 발명의 창상 피복재용 페이스트는 종래의 시트형 무세포 진피 기질의 적용이 어려운 부위나 국소 부위에도 용이하게 적용이 가능하며, 즉시 사용 가능한 ready-to-use 제품으로 사용이 편리하며 심각한
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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